Table 5 Clinicopathological characteristics of breast cancers with and without recurrence or metastasis
Variable | Recurrence or Metastasis N = 8 | No Recurrence or Metastasis N = 56 | No. of all | P value |
|---|---|---|---|---|
Age | ||||
  < 40 years | 3 (37.5) | 11 (19.6) | 14 (21.9) | 0.253 |
  ≥ 40 years | 5 (62.5) | 45 (80.4) | 50 (78.1) | |
Histopathological type | ||||
 Ductal carcinoma in situ | 1 (12.5) | 7 (87.5) | 8(12.5) | 1.000 |
 Invasive ductal carcinoma | 7 (12.5) | 49 (87.5) | 56 (87.5) | |
Tumor size | ||||
 T1 | 2 (25.0) | 21 (37.5) | 23 (35.9) | 0.073 |
 T2 | 3 (37.5) | 30 (53.6) | 33 (51.6) | |
 T3 | 3 (37.5) | 5 (8.9) | 8 (12.5) | |
Node metastatic | ||||
 N- | 5 (62.5) | 39 (69.6) | 44 (68.8) | 0.683 |
 N +  | 3 (37.5) | 17 (30.4) | 20 (31.2) | |
Biologic feature | ||||
 unfavorable | 4(50.0) | 12(21.4) | 16(25.0) | 0.081 |
 Intermediate/ favorable | 4(50.0) | 44(78.6) | 48(75.0) | |
Nuclear grade | ||||
 Low/Intermediate | 4 (50.0) | 50(89.3) | 54 (84.4) | 0.004 |
 high | 4 (50.0) | 6 (10.7) | 10(15.6) | |
ER | ||||
 ER- | 5 (62.5) | 14 (25.0) | 19 (29.7) | 0.030 |
 ER +  | 3 (37.5) | 42 (75.0) | 45 (70.3) | |
PR | ||||
 PR- | 5 (62.5) | 15 (26.8) | 20 (31.2) | 0.041 |
 PR +  | 3 (37.5) | 41 (73.2) | 44 (68.8) | |
HER2 | ||||
 HER2- | 7 (87.5) | 35 (62.5) | 42 (65.6) | 0.164 |
 HER2 +  | 1 (12.5) | 21 (37.5) | 22 (34.4) | |
p53 | ||||
 p53- | 1 (12.5) | 28 (50.0) | 29 (45.3) | 0.046 |
 p53 +  | 7 (87.5) | 28 (50.0) | 35 (54.7) | |
Ki67 | ||||
 Ki67- | 0 (0.0) | 14 (25.0) | 14 (21.9) | 0.110 |
 Ki67 +  | 8(100.0) | 42 (75.0) | 50 (78.1) | |
Molecular substype | ||||
 Luminal A | 0 (0.0) | 18 (32.1) | 18 (28.1) | 0.052 |
 Luminal B | 3 (37.5) | 26 (46.4) | 29 (45.3) | |
 HER2 over-expression | 1 (12.5) | 4 (7.2) | 5 (7.8) | |
 Triple negative | 4 (50.0) | 8 (14.3) | 12 (18.8) | |
Triple negative | ||||
 No | 4 (50.0) | 48 (85.7) | 52 (81.2) | 0.015 |
 Yes | 4 (50.0) | 8 (14.3) | 12 (18.8) | |