MR imaging phenotypes and features associated with pathogenic mutation to predict recurrence or metastasis in breast cancer

Table 1 Pathogenic gene mutations in 15 patients with 17 cancers

Gene	Mutation	Age at diagnosis	Family history	Mutation type
BRCA1	c.3359_3363delTTAAT	48	Sister	frameshift
	c.5470_5477delATTGGGCA	30	Aunt	frameshift
	c.5136G > A^a	29	Mother	nonsense
	c.5153-1G > A^a	47	Sister	splice-site variants
	chr17:41246509delG	41	Mother	frameshift
	chr17:41226484insC	44	Sister	frameshift
	c.5470_5477delATTGGGCA	53	Aunt	frameshift
	chr17:41226455delG	49	Mother	frameshift
	c.2138C > G	34	Mother, Aunt	nonsense
BRCA2	chr13:32913702DelTACT	51	Mother	frameshift
BRCA2	chr13:32914936InsTA	41	Sister	frameshift
BAP1	chr3:52440911InsC	26	Mother	frameshift
BRIP1	chr17:59793425C > A	41	Sister	splice-site variants
MSH6	chr2:48010546delC	49	Mother	frameshift
ATM	c.2414C > T	32	Aunt	nonsense

ISSN: 1471-2407