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Table 3 Methylation percentages between the studied groups in the six CpG sites

From: PCDH17 gene promoter methylation status in a cohort of Egyptian women with epithelial ovarian cancer

CpG site

Control group

Malignant group

P

CpG 1

  

0.009*

 Median (IQR)

3 (0-5)

11 (3-19)

CpG 2

  

0.025*

 Median (IQR)

2 (0-6)

9 (0-18)

CpG 3

  

0.025*

 Median (IQR)

6 (0-21)

24 (9-47)

CpG 4

  

0.036*

 Median (IQR)

5 (0-11)

9 (4-33)

CpG 5

  

0.036*

 Median (IQR)

3 (0-9)

10 (2-37)

CpG 6

  

0.082

 Median (IQR)

4 (0-12)

13 (0-29)

Average CpG

  

0.018*

 Median (IQR)

5 (2.83-10.5)

11.83 (5.67-35.5)

CpG site

a) Control without mass

b) Control with mass

c) Malignant group

P1

P2

P3

CpG 1

   

0.016*

0.255

0.004*

 Median (IQR)

3.50 (3.0 – 7.0)

0.0 (0.0 – 4.0)

11 (3-19)

CpG 2

   

0.078

> 0.05

> 0.05

 Median (IQR)

2.50 (0.0 – 6.0)

0.0 (0.0 – 6.0)

9 (0-18)

CpG 3

   

0.055

> 0.05

> 0.05

 Median (IQR)

5.50 (0.0 – 12.0)

11.0 (1.0 – 23.0)

24 (9-47)

CpG 4

   

0.044*

0.013*

0.253

 Median (IQR)

1.50 (0.0 – 11.0)

6.0 (3.0 – 12.50)

9 (4-33)

CpG 5

   

0.074

> 0.05

> 0.05

 Median (IQR)

3.0 (0.0 – 6.0)

4.0 (1.0 – 13.5)

10 (2-37)

CpG 6

   

0.075

> 0.05

> 0.05

 Median (IQR)

2.0 (0.0 – 5.0)

6.0 (1.50 – 16.5)

13 (0-29)

Average CpG

   

0.036*

0.014*

0.123

 Median (IQR)

3.17 (2.67 – 6.67)

5.83 (3.17 – 12.67)

11.83 (5.67-35.5)

  1. p p value, IQR interquartile range, P1 p value between groups a,b and c. P2 p value between groups a and c. P3 p value between groups b and c
  2. *P value is statistically significant at p ≤ 0.05