Table 2 Univariate analysis of differentiation syndrome in patients with acute promyelocytic leukemia
Clinical characteristics | Patients without DS(n = 32cases) | Patients with DS(n = 53 cases) | Statistical value (χor Z value) | P-value |
|---|---|---|---|---|
WBC count at diagnosis (× 109/L) | 1.77(0.19 ~ 192.63) | 4.92(0.46 ~ 108.75) | 1.968 | 0.049 |
WBC count at diagnosis≥3 × 109/L | 26.1%(12/46) | 73.9%(34/46) | 5.708 | 0.017 |
WBC count at diagnosis< 3 × 109/L | 51.3%(20/39) | 48.7%(19/39) | ||
Percentage of monocytes at diagnosis (%) | 23.15(2.3 ~ 88.4) | 41.8(0.9 ~ 85.9) | 2.037 | 0.042 |
WBC on Day 5 | ||||
 WBC count on Day 5 ≥ 10 × 109/L | 20.5%(8/39) | 79.5%(31/39) | 5.341 | 0.021 |
 WBC count on Day 5 < 10 × 109/L | 46.7%(14/30) | 53.3%(16/30) | ||
Peak WBC (×109/L) | 18.26(1.56 ~ 194.43) | 32.70(4.35 ~ 112.85) | −2.807 | 0.005 |
Peak WBC count ≥16 × 109/L | 22.2%(12/54) | 77.8%(42/54) | 12.112 | 0.001 |
Peak WBC count < 16 × 109/L | 68.8%(11/16) | 31.3%(5/16) | ||
Percentage of bone marrow promyelocytes (%) | 77.5(5.0 ~ 96.5) | 85.0(26.0 ~ 95.5) | −2.039 | 0.041 |
Time for bone marrow to achieve remission(day) | 22(17 ~ 35) | 26(17 ~ 41) | −1.835 | 0.067 |
Transfusion of RBC (U) | 5.0(0 ~ 15) | 8.0(0 ~ 22) | −3.277 | 0.001 |
Transfusion of PLT (therapeutic volumes) | 1(0 ~ 6) | 2(0 ~ 12) | −3.769 | 0.000 |