Table 2 Survival outcomes
From: Trends in overall mortality among US veterans with primary myelofibrosis
|  | Overall Population | < 2 Modified IPSS Risk Factors | ≥2 Modified IPSS Risk Factors | |||
|---|---|---|---|---|---|---|
Pre-RUX Approval (n = 193) | Post-RUX Approval (n = 974) | Pre-RUX Approval (n = 113) | Post-RUX Approval (n = 777) | Pre-RUX Approval (n = 80) | Post-RUX Approval (n = 197) | |
OS, median, y (95% CI) | 1.7 (1.2–2.6) | NR (3.4–NR) | 3.4 (2.7–4.5) | NR (3.5–NR) | 0.9 (0.8–1.3) | 1.6 (1.1–2.0) |
Overall mortality rate,a n (%) | 137 (79.8) | 242 (47.3) | 63 (66.5) | 134 (42.1) | 74 (97.5) | 108 (72.5) |
1-year mortality rate,a n (%) | 73 (37.8) | 164 (17.6) | 31 (27.4) | 87 (11.8) | 42 (52.5) | 77 (40.0) |
2-year mortality rate,a n (%) | 102 (53.0) | 216 (26.3) | 43 (38.2) | 116 (18.1) | 59 (73.8) | 100 (57.1) |
3-year mortality rate,a n (%) | 113 (59.5) | 238 (35.1) | 48 (43.5) | 131 (25.8) | 65 (81.6) | 107 (67.9) |
5-year mortality rate,a n (%) | 137 (79.8) | – | 63 (66.5) | – | – | – |