Table 1 Univariate and multivariate analyses of OS in advanced gastric cancer patients

 Male

Ref.

 Female

1.258

0.910–1.739

0.165

  ≤ 60

Ref.

  > 60

1.102

0.818–1.484

0.523

 Upper

Ref.

 Middle

1.106

0.721–1.697

0.645

 Lower

1.134

0.947–1.357

0.170

  < 3

Ref.

  ≥ 3

1.061

0.928–1.211

0.388

 Open

Ref.

 Laparoscope

0.923

0.534–1.594

0.773

 Poor

Ref.

Ref.

 Well- moderate

0.386

0.223–0.666

0.001

0.452

0.259–0.788

0.005

 Proximate GR

Ref.

 Distal GR

1.468

0.204–10.559

0.703

 Total GR

1.212

0.453–3.246

0.702

 Tumor residue

Ref.

Ref.

 Tumor regression

0.603

0.400–0.909

0.016

0.629

0.413–0.958

0.031

 Normal

Ref.

Ref.

 Unnormal

1.412

1.021–1.952

0.037

1.304

0.931–1.827

0.122

pre- NACT PLT

0.011

 Normal

Ref.

Ref.

 Below normal

2.097

1.350–3.258

0.001

1.283

0.736–2.236

0.379

 Above normal

0.558

0.391–0.797

0.001

0.337

0.161–0.706

0.004

post- NACT Lym

0.555

 Normal

Ref.

Ref.

 Below normal

1.894

1.389–2.585

< 0.001

1.718

0.553–5.340

0.350

 Above normal

0.611

0.474–1.287

0.333

0.866

0.513–1.464

0.592

 α > −61%

Ref.

Ref.

 α ≤ −61%

2.006

1.373–2.930

<  0.001

1.279

0.823–1.986

0.273

 α ≤ −19%

Ref.

Ref.

 α > −19%

3.914

2.872–5.334

< 0.001

3.193

2.194–4.649

<  0.001

 α > 12%

Ref.

Ref

 α ≤ 12%

2.154

1.593–2.913

< 0.001

1.016

0.704–1.468

0.931

 α > 173%

Ref.

Ref.

 α ≤ 173%

1.625

1.056–2.500

0.027

1.375

0.877–2.154

0.165

Change of Lym

0.099

 Up-regulated

Ref.

Ref.

 Non-regulated

2.775

1.135–6.783

0.025

2.550

0.918–7.086

0.073

 Down-regulated

5.293

2.100–13.342

< 0.001

3.576

1.114–11.478

0.032

Change of PLT

0.156

 Down-regulated

Ref.

Ref.

 Non-regulated

0.774

0.567–1.058

0.109

1.364

0.938–1.983

0.104

 Up-regulated

4.384

1.917–10.028

< 0.001

1.710

0.658–4.446

0.271