Table 2 Univariate and multivariate analyses for overall survival in all patients
Characteristics | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | p | HR | 95% CI | p | |
Age (years) | ||||||
≤18 | 1 | 0.006 | 1 | 0.587 | ||
>18 | 1.654 | 1.160-2.361 | 1.105 | 0.770-1.587 | ||
Sex | ||||||
Male | 1 | 0.281 | ||||
Female | 0.809 | 0.551-1.189 | ||||
location | ||||||
Extremities | 1 | 0.264 | ||||
Non-extremities | 1.340 | 0.802-2.240 | ||||
Tumor size | ||||||
≤8cm | 1 | <0.001 | 1 | 0.015 | ||
>8cm | 2.502 | 1.730-3.628 | 1.647 | 1.101-2.464 | ||
Enneking | ||||||
I | 1 | <0.001 | 1 | <0.001 | ||
II | 5.164 | 2.073-12.864 | 3.206 | 1.249-8.229 | ||
III | 11.484 | 4.539-29.057 | 6.650 | 2.569-17.216 | ||
Subtype | ||||||
Conventional osteosarcoma | 1 | 0.612 | ||||
Telangiectatic osteosarcoma | 1.619 | 0.781-3.356 | 0.196 | |||
Small cell osteosarcoma | 0.352 | 0.049-2.531 | 0.300 | |||
Parosteal osteosarcoma | 1.008 | 0.573-1.775 | 0.977 | |||
Periosteal osteosarcoma | 0.344 | 0.048-2.473 | 0.289 | |||
High grade surface osteosarcoma | 1.335 | 0.185-9.620 | 0.775 | |||
Low-grade central osteosarcoma | 0.851 | 0.475-1.526 | 0.589 | |||
Pathological fracture | ||||||
No | 1 | 0.905 | ||||
Yes | 0.967 | 0.554-1.688 | ||||
Surgery | ||||||
No | 1 | 0.302 | ||||
Yes | 0.768 | 0.466-1.267 | ||||
NACT | ||||||
No | 1 | 0.001 | 1 | 0.017 | ||
Yes | 0.557 | 0.391-0.793 | 0.641 | 0.446-0.923 | ||
alkaline phosphatase | ||||||
Normal | 1 | 0.016 | 1 | 0.319 | ||
Elevated | 1.574 | 1.089-0.273 | 1.216 | 0.828-1.786 | ||
CAR | ||||||
LCAR | 1 | 1 | <0.001 | |||
HCAR | 3.284 | 2.278-4.736 | <0.001 | 2.265 | 1.535-3.343 | |
PLR | ||||||
LPLR | 1 | 0.001 | 1 | 0.977 | ||
HPLR | 1.825 | 1.272-2.619 | 1.006 | 0.675-1.498 | ||
NLR | ||||||
LNLR | 1 | <0.001 | 1 | 0.001 | ||
HNLR | 2.794 | 1.874-4.165 | 2.001 | 1.309-3.058 | ||