Fig. 7
Rotenone and tamoxifen synergize to induce collateral sensitivity – Isobole analysis of interactions between tamoxifen and rotenone to induce collateral sensitivity in drug resistant cells (CHORC5). Rotenone shows strong synergistic effect with 0.75 µM tamoxifen at 0.4 nM (Δ) and 1.3 nM (X) for CHORC5. By contrast, at 0.4 nM (Δ) and 1.3 nM (X) rotenone concentrations, with 4 µM tamoxifen, AuxB1 shows moderate to antagonistic drug interactions