Fig. 5
Tamoxifen treatment modulates the oxidative status of drug resistant cells – The effects of increasing concentrations of tamoxifen on the oxidative status of AuxB1 and CHORC5 cells. Panel (A) and (B) shows drug sensitive (AuxB1) and -resistant (CHORC5) cells incubated without and with tamoxifen (1 and 5 µM) for 24 h followed by a measure of total reduced cellular thiols levels and reactive oxygen species (ROS) in cells. Graphs represent the mean ± SD of three independent experiments done in triplicates. (****) indicates, P < 0.0005, statistically significant difference