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Fig. 4 | BMC Cancer

Fig. 4

From: The anti-estrogen receptor drug, tamoxifen, is selectively Lethal to P-glycoprotein-expressing Multidrug resistant tumor cells

Fig. 4

Overexpression of huBCL-2 diminishes collateral sensitivity to tamoxifen—Panel (A) shows a Western blot of cell extracts from AuxB1, CHORC5, and CHORC5 cells transfected with recombinant human Bcl-2 (CHORC5Bcl−2) probed with anti-Bcl-2 antibody or human-specific anti-Bcl-2 rabbit mAb together with anti-β-actin mAb as loading control. Panel (B) shows the proliferation of AuxB1, CHORC5 and CHORC5BCL2 cell in the presence of increasing concentrations of tamoxifen without and with 2 μM PSC-833. Graphs represent the mean ± SD of three independent experiments done in triplicates

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BMC Cancer

ISSN: 1471-2407

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