Fig. 3
Tamoxifen promotes apoptosis in drug resistant cells—Cells were treated for 24 h with tamoxifen prior to quantification of apoptotic cells by flow cytometry or staining with Hoechst 33,258. Panel (A) shows the percentage of AuxB1 and CHORC5 cells stained with FITC-conjugated annexin-V following 24 h treatment with tamoxifen (2.5–10 μM) relative to solvent control. (****), (***) indicates, P < 0.0005, statistically significant difference. Panel (B) shows Hoechst 33,258 stained AuxB1 and CHORC5 cells following 24 h treatment with 5 μM tamoxifen versus solvent control treated cells