Table 4 The roles of CR signature genes in various cancers
From: Cuproptosis regulatory genes greatly contribute to clinical assessments of hepatocellular carcinoma
Gene | Study | Cancer type | Function |
|---|---|---|---|
FDX1 | PMID: 32304229 | CRC | FDX1 is involved in tumor suppression through mediating TP73 tumor suppressor |
PMID: 36226187 | HCC | FDX1 could inhibit the proliferation of HepG2 cells with the presence of copper ions | |
DLAT | PMID: 26279757 | GC | DLAT can promote the proliferation and carbohydrate metabolism of GC cells |
PMID: NA | HCC | Unclear | |
CDKN2A | PMID: 32594303 | CC | CDKN2A inhibits cell proliferation and invasion in CC through AKT/mTOR pathway |
PMID: 28854942 | HCC | CDKN2A induces cell cycle arrest in G1 and G2 phases, its mutation is one of the most common molecular anomalies in HCC | |
GLS | PMID: 24276018 | Glioma | GLS silencing synergize with oxidative stress against proliferation of glioma cells |
PMID: 30786811 | HCC | GLS promotes cancer progression and metabolism with the mediation of MET |