Table 3 The effects of CR risk levels on multiple metabolic pathways
From: Cuproptosis regulatory genes greatly contribute to clinical assessments of hepatocellular carcinoma
Metabolic pathway | Enriched phenotype | Study (PMID) | Function in cancer |
|---|---|---|---|
Glycolysis | High CR risk | 32631382 | Glycolysis is closely associated with proliferation, immune evasion, invasion, metastasis, angiogenesis, and drug resistance in cancers |
Nucleotide Metabolism | High CR risk | 34138729 | Nucleotide metabolism is necessary for tumor proliferation and mediates oncogenic mutations, such as P53 mutation |
Cholesterol Biosynthesis | NS | 34117857 | Cholesterol is an essential component of cell membranes. Aberrant cholesterol metabolism enhances malignant behaviors of tumor cells |
FA metabolism | NS | 23791484 | Tumor proliferation requires FAs for synthesis of membranes and signaling molecules |
Glutamate and Glutamine Metabolism | NS | 23999442 | Glutamine participates in energy formation, redox homeostasis, macromolecular synthesis, and signaling in cancer cells |