Table 2 The effects of high CR risk on tumor immune microenvironment
From: Cuproptosis regulatory genes greatly contribute to clinical assessments of hepatocellular carcinoma
Immune cell | Variation trend | Roles in tumor immune response | Final effect on antitumor immune |
|---|---|---|---|
B cells memory | Increased | Memory B cells are critical for the formation of germinal center and plasma cell | Favorable |
T cells CD8 | Decreased | CD8 + T cells are the most central anti-tumor effectors for their potent cytotoxic effects | Unfavorable |
Macrophages M0 | Increased | The polarization of macrophage M1/M2 can determine the direction of anti-tumor immunity | Uncertain |
Macrophages M1 | Decreased | M1 macrophages contribute to eradicating cancerous cells through mediating cytotoxicity and ADCC pathways | Unfavorable |
Macrophages M2 | Increased | M2 macrophages can suppress the functions of T cells | Unfavorable |