Table 1 shows the follow-up schedule

ENROLLMENT:

 Eligibility screening

X

 Informed consent

X

 Randomization

X

INTERVENTIONS:

 Omitting IMNI

X

 With IMNI

X

ASSESSMENTS:

 Physical Examination

X

X

X

X

X

X

X

X

X

X

 Complete blood cell count

X

X

X

X

X

X

X

X

X

X

 Thyroid function

X

X

X

X

X

X

X

X

X

 Myocardial enzyme

X

X

X

X

X

X

X

X

X

 Chest CT scan

X

X

X

X

X

X

 Mammography

X

X

X

X

X

 Ultrasound for Breast and regional nodes

X

X

X

X

X

X

X

X

 ECG

X

X

X

X

X

X

X

X

 Echocardiography

X

X

X

X

X

X

X

X