Effect of chlorhexidine mouthrinse on prevention of microbial contamination during EBUS-TBNA: a randomized controlled trial

Table 4 Primary and Secondary Outcomes

	Chlorhexidine Mouthrinse (n = 51)	Usual Care (n = 55)	P Value^a	Median difference (95% CI)^b
Primary outcome
CFU counts in aerobic culture, CFU/mL	10 (10–40)	20 (10–40)	0.70	−10 (−20 to 10)
Secondary outcomes
CFU counts in anaerobic culture, CFU/mL	0 (0–13)	0 (0–20)	0.41	0 (−10 to 0)
Fever within 24 hours after EBUS-TBNA (n = 105)^c	6 (11.8)	3 (5.6)	0.31
Infectious complications within 4 weeks after EBUS-TBNA (n = 105)^d	0 (0)	0 (0)

Data are presented as number (%) or median (interquartile range). CFU Colony forming unit, EBUS-TBNA Endobronchial ultrasound-guided transbronchial needle aspiration
^aP-value from the Mann–Whitney U test or Fisher’s exact test. ^bCI from a bootstrap approach using the percentile method. ^cOne participant was excluded from the analysis owing to loss of 24-hour follow-up. ^dOne participant was excluded from the analysis owing to loss of 4-week follow-up

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