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Fig. 2 | BMC Cancer

Fig. 2

From: MYEOV overexpression induced by demethylation of its promoter contributes to pancreatic cancer progression via activation of the folate cycle/c-Myc/mTORC1 pathway

Fig. 2

MYEOV mRNA expression and DNA methylation status in TCGA-PAAD patients. A, Schematic structure of the promoter region of MYEOV gene. Arrowheads indicate the location of the CpG region where information on DNA methylation status is recorded in the TCGA. TSS; transcriptional start site. B, Heatmap of pancreatic cancer specimens and noncancerous tissues of the TCGA dataset. The expression of MYEOV and the methylation status of six CpG sites in the region indicated in A are depicted. Each column represents individual specimens. Specimens are sorted in descending order based on TPM values for MYEOV. DNA methylation status is indicated by β-values ranging from 0 to 1 (if cytosine is not methylated at all, the value is 0, and 1 if it is fully methylated). C, Correlation between the methylation levels of six CpG regions (x-axis) and the expression levels of MYEOV mRNA (y-axis) in PAAD samples from the TCGA dataset. The correlation between methylation and expression levels was calculated by Spearman’s rank correlation coefficient. Purple circle, tumor; green circle, normal

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BMC Cancer

ISSN: 1471-2407

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