Table 3 Frequency of detected point mutations in the cell lines
From: Increased HRD score in cisplatin resistant penile cancer cells
Genes | UKF-PEC1 | UKF-PEC1r5-FU500 | UKF-PEC1rCDDP2500 | UKF-PEC1rCDDP2500 r 5-FU500 | Assessmenta |
|---|---|---|---|---|---|
BRCA2 | - | - | - | 4,39** | 3 |
CDK12 | 4,84** | - | - | - | 3 |
CDKN2A | 98.86 | 98.85 | 97.72 | 98.45 | 1 |
CREBBP | - | - | 45.1 | - | 3 |
FGF3 | - | - | 14.58 | - | 3 |
FGFR4 | 41.01 | 47.51 | 53.67 | 69.15 | 5 |
MLH1 | - | 5.66 | - | - | 5 |
NOTCH3 | 34.88 | 43.88 | 23.28 | 30.59 | 3 |
NTRK2 | - | - | 17.51 | - | 3 |
PIK3CA | - | - | 4,3** | - | 3 |
PIK3CB | - | - | 17.43 | - | 3 |
RAD50 | - | - | 16.05 | - | 3 |
RAF1 | 66.73 | 76.85 | 56.45 | 66.7 | 1 |
RB1 | 100 | 100 | 100 | 97.64 | 3.4 |
SLX4 | 65.16 | 36.1 | 74.16 | 60.89 | 3 |
TERT | 86.66 | - | - | - | 3.5 |
TP53 | 38.26 | 33.75 | 82.3 | 97.05 | 1 |
TSPAN31 | - | 3** | - | - | 3 |