Fig. 1

LL-2-CM promoted cell proliferation and migration of BMDMs. BMDMs were cultured in different concentrations of LL-2-CM. Viable cells were detected by CCK8 A. Protein concentrations in different culture medium B and viability of BMDMs in different concentration of FBS C was tested to verify the optimal LL-2-CM treatment method. P values were calculated by one-way ANOVA and Tukey test. Monolayer of BMDMs were scratched and cultured in 50 \(\mathrm{\%}\) LL-2-CM. Pictures were taken at the same field of vision before and after 24 h. The scratch closure rates were calculated D. BMDMs were loaded in the up chamber of transwells and 50 \(\mathrm{\%}\) LL-2-CM was loaded in the down chamber of transwells for 12 h. The cells crossing through the transwell membrane were stained and counted E. P values were calculated by Student’s t-test