Knowledge clip | Content |
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1 | • difference between germline and somatic pathogenic variants • difference between genetic testing in blood and in tumor tissue • role of pathogenic variants in carcinogenesis |
2 | • indications for germline genetic testing in prostate cancer • risks of developing cancer for male and female family members with a pathogenic germline variant • preventive measures for breast/ovarian cancer for female family members • PSA screening for male family members carrying a pathogenic germline variant in BRCA2 |
3 | • protocol for mainstream genetic testing |
4 | • advice about discussing germline genetic testing with patients • a simulated conversation between a urologist and a patient • an interview with a prostate cancer patient who carries a pathogenic germline variant |