Features | Groups (n) | gH2AX, % median (range) n = 75 | P | RPA2, % median (range) n = 74 | P | sTIL, % median (range) n = 76 | P | iTIL, % median (range) n = 76 | P | tcPD-L1,% median (range) n = 73 | P | icPD-L1, % median (range) n = 73 | P |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age at diagnosisa,c | ≤ 50 (5) > 50 (71) | 63 (30–85) 42 (5–85) | 0.711 | 44 (20–73) 44 (3–81) | 0.800 | 12 (5–30) 5 (0–60) | 0.061 | 0 (0–5) 0 (0–20) | 0.052 | 23 (0–100) 3 (0–100) | 0.525 | 40 (5–60) 5 (0–80) | 0.461 |
Gradea | 1 (2) 2 (10) 3 (64) | 70 (70–70) 42 (6–85) 43 (5–85) | 0.860 | 20 (20–20) 52 (3–75) 44 (3–81) | 0.985 | 5 (5–5) 2 (0–40) 5 (0–60) | 0.404 | 0 (0–0) 1 (0–20) 0 (0–20) | 0.907 | 0 (0–0) 1 (0–40) 5 (0–100) | 0.138 | 16 (1–30) 0 (0–80) 20 (0–70) | 0.248 |
Pathological tumor size (mm)a,c | ≤ 20 (20) 21–50 (38) > 50 (17) | 60 (8–85) 36 (6–85) 40 (5–79) | 0.154 | 45 (0–60) 44 (3–81) 32 (4–80) | 0.385 | 5 (0–60) 4 (0–40) 2 (0–50) | 0.093 | 0 (0–20) 1 (0–20) 1 (0–5) | 0.074 | 0 (0–80) 7 (0–100) 10 (0–80) | 0.033 | 3 (0–60) 18 (0–80) 10 (0–60) | 0.937 |
Pathological nodal stagea | N0 (57) N1 (7) N2 (2) N3 (3) | 43 (6–85) 32 (5–83) 49 (19–79) 27 (11–28) | 0.255 | 40 (3–80) 45 (4–65) 53 (25–80) 44 (38–75) | 0.529 | 5 (0–50) 5 (0–50) 10 (0–20) 10 (7–25) | 0.284 | 0 (0–20) 0 (0–2) 0 (0–0) 0 (0–2) | 0.162 | 5 (0–100) 7 (0–80) 8 (6–10) 3 (0–15) | 0.717 | 20 (0–80) 10 (0–60) 35 (0–70) 1 (0–15) | 0.644 |
ER b | > 10% (9) < 10% (67) | 47 (8–80) 43 (5–85) | 1.000 | 50 (7–81) 44 (3–80) | 0.399 | 5 (0–40) 5 (0–60) | 0.452 | 1 (0–20) 0 (0–20) | 0.673 | 10 (0–80) 3 (0–100) | 0.240 | 20 (0–80) 5 (0–70) | 0.420 |
PRb | > 10% (2) < 10% (74) | 42 (8–75) 43 (5–85) | 0.833 | 45 (20–70) 44 (3–81) | 0.831 | 4 (2–5) 5 (0–60) | 0.909 | 0 (0–0) 0 (0–20) | 0.295 | 0 (0–0) 3 (0–100) | 0.171 | 30 (0–60) 10 (0–80) | 0.804 |
HER2b | Positive (3) Negative (73) | 67 (11–73) 43 (5–85) | 0.889 | 69 (44–70) 43 (3–81) | 0.199 | 50 (25–60) 5 (0–50) | 0.001 | 2 (1–2) 0 (0–20) | 0.222 | 1 (0–15) 3 (0–100) | 0.743 | 1 (0–30) 10 (0–80) | 0.743 |
Ki-67b | < 20% (9) ≥ 20% (67) | 37 (6–85) 44 (5–85) | 0.696 | 30 (3–75) 44 (3–81) | 0.836 | 3 (0–40) 5 (0–60) | 0.565 | 0 (0–20) 0 (0–20) | 0.604 | 10 (0–100) 3 (0–100) | 0.560 | 4 (0–80) 10 (0–70) | 0.972 |
Basal phenotypeb | Yes (13) No (61) | 44 (5–85) 40 (8–83) | 0.925 | 46 (3–81) 38 (3–80) | 0.739 | 5 (0–60) 5 (0–30) | 0.563 | 1 (0–20) 0 (0–20) | 0.048 | 3 (0–100) 3 (0–80) | 0.794 | 13 (0–80) 1 (0–60) | 0.917 |