Table 1 Patient, tumor and treatment characteristics between conventional fractionation (CF) and hypofractionation (HF) groups
All patients (n = 1727) | Conventional fractionated (n = 1419) | Hypofractionated (n = 308) | P value | |
|---|---|---|---|---|
Age (years), mean (SD) (nT = 1727) | 58.8 (13.8) | 57.8 (13.5) | 63.0 (14.5) | < 0.0001 |
BMI (kg/m2), median [IQR] (nT = 1017) | 26.6 [23.2; 30.9] | 26.6 [23.2; 30.9] | 26.4 [22.7; 30.4] | 0.41 |
Active Smokers (nT = 1478) | 207 (14.0) | 189 (15.2) | 18 (7.6) | 0.002 |
Diabetes (nT = 635) | 79 (12.4) | 68 (12.3) | 11 (13.1) | 0.85 |
Menopausal status (nT = 536) | ||||
Menopause | 464 (86.6) | 406 (85.1) | 58 (98.3) | 0.017 |
Perimenopause | 26 (4.8) | 25 (5.2) | 1 (1.7) | |
No Menopause | 46 (8.6) | 46 (9.6) | 0 | |
Breast side (Right) (nT = 1668) | 812 (48.7) | 687 (49.4) | 125 (45.0) | < 0.0001 |
Quadrant (nT = 1343) | ||||
Upper-Outer | 561 (41.8) | 478 (41.1) | 83 (44.1) | |
Overlapping lesion of breast | 295 (22.0) | 256 (22.2) | 39 (20.7) | < 0.0001 |
Upper-Inner | 153 (11.4) | 128 (11.1) | 24 (12.8) | |
Central portion of breast | 140 (10.4) | 115 (10.0) | 25 (13.3) | |
Lower-Outer | 108 (8.0) | 96 (8.3) | 12 (6.4) | |
Lower-Inner | 72 (5.4) | 69 (6.0) | 3 (1.6) | |
Axillary tail of breast | 14 (1.0) | 12 (1.0) | 2 (1.1) | |
Molecular subtype (nT = 1163) | ||||
Triple negative | 155 (13.3) | 135 (13.4) | 20 (13.2) | 0.016 |
HR- HER2+ | 95 (8.2) | 85 (8.4) | 10 (6.6) | |
HR+ HER2+ | 132 (11.3) | 106 (10.5) | 26 (17.1) | |
HR+ HER2- | 781 (67.2) | 685 (67.8) | 96 (63.2) | |
Grade (nT = 1274) | 0.1011 | |||
1 | 187 (14.7) | 150 (13.8) | 37 (19.8) | |
2 | 607 (47.6) | 524 (48.2) | 83 (44.4) | |
3 | 480 (37.7) | 413 (38.0) | 67 (35.8) | |
pT stage (nT = 1333) | ||||
0 | 136 (10.2) | 120 (10.5) | 16 (8.3) | 0.1260 |
1 | 458 (34.4) | 402 (35.2) | 56 (29.2) | |
2 | 547 (41.0) | 454 (39.8) | 93 (48.4) | |
3 | 153 (11.5) | 134 (11.7) | 19 (9.9) | |
4 | 39 (2.9) | 31 (2.7) | 8 (4.2) | |
pN stage (nT = 1359) | ||||
pN+ | 1021 (75.1) | 865 (74.3) | 156 (80.0) | 0.0879 |
Breast/Chest Wall (nT = 1727) | ||||
Breast | 966 (55.9) | 746 (52.6) | 220 (71.4) | < 0.0001 |
Chest wall | 761 (44.1) | 673 (47.4) | 88 (28.6) | |
Axillary irradiation (nT = 1727) | 87 (5.0) | 63 (4.4) | 24 (7.8) | 0.01 |
Technique (nT = 1727) | ||||
IMRT | 781 (45.2) | 523 (36.9) | 258 (83.8) | < 0.0001 |
3D | 946 (54.8) | 896 (63.1) | 50 (16.2) | |
Use of electrons (nT = 1727) | 531 (30.8) | 519 (36.6) | 12 (3.9) | < 0.0001 |
Tumor bed boost (nT = 1727) | 795 (46.0) | 679 (47.9) | 116 (37.7) | 0.001 |
Photon Energy (nT = 1727) | ||||
Standard | 833 (48.2) | 574 (40.5) | 259 (84.1) | < 0.0001 |
High | 894 (51.8) | 845 (59.5) | 49 (15.9) | |
Center (nT = 1727) | < 0.0001 | |||
Center 1 | 1035 (59.9) | 900 (63.4) | 135 (43.8) | |
Center 2 | 574 (33.2) | 467 (32.9) | 107 (34.7) | |
Center 3 | 118 (6.8) | 52 (3.7) | 66 (21.4) |