Fig. 2

Identification of a stemness-related inhibitory immune checkpoint in pancreatic cancer. A Differential levels of mRNAsi scores in pancreatic cancer and paired normal tissues. B Volcano plot for differentially expressed genes between pancreatic cancers with high vs. low mRNAsi scores. C Expression profiles of the inhibitory immune checkpoints in pancreatic cancers with high vs. low mRNAsi scores. D Ridgeline plot for gene set enrichment analysis of differentially expressed genes between pancreatic cancers with high vs. low mRNAsi scores. E Spearman's correlation of the inhibitory immune checkpoints with invasive cell-enriched signature (ICS) in pancreatic cancer. The threshold of the correlation coefficient was set at 0.5. F Spearman's correlation of the inhibitory immune checkpoints with Msi⁺ tumour-initiating cell-enriched signature (MTS) in pancreatic cancer. The threshold of the correlation coefficient was set at 0.5. G Spearman's correlation between ICS and MTS in pancreatic cancer. H Spearman’s correlation between CEACAM5 expression and ICS in pancreatic cancer. I Spearman's correlation between CEACAM5 expression and MTS in pancreatic cancer