Table 3 Common adverse events
Adverse Events | All Grades | Grade ≥ 3 | ||||
|---|---|---|---|---|---|---|
TC group (n = 34) | T group (n = 61) | P | TC group (n = 34) | T group (n = 61) | P | |
Any TEAE (≥ 1) | 24(70.6) | 36(59.0) | 0.262 | 11(32.4) | 8(13.1) | 0.025 |
Leukopenia | 18(52.9) | 2(3.3) | P < 0.001 | 3(8.9) | 0(0.0) | 0.018 |
Neutropenia | 16(47.1) | 3(4.9) | P < 0.001 | 5(14.7) | 0(0.0) | 0.002 |
Anemia | 16(47.1) | 12(19.7) | 0.005 | 3(8.9) | 2(3.3) | P < 0.001 |
Thrombocytopenia | 17(50.0) | 5(8.2) | P < 0.001 | 3(8.9) | 0(0.0) | 0.018 |
Liver dysfunction | 11(32.3) | 9(14.8) | 0.044 | 2(5.8) | 2(3.3) | 0.545 |
Creatinine elevation | 5(14.7) | 4(6.6) | 0.194 | 0(0.0) | 0(0.0) | |
Diarrhea | 9(26.5) | 13(21.3) | 0.568 | 1(2.9) | 1(1.6) | 0.672 |
Vomiting | 7(20.6) | 2(3.3) | 0.006 | 0(0.0) | 0(0.0) | |
Stomatitis | 8(23.5) | 11(18.0) | 0.521 | 0(0.0) | 0(0.0) | |
Rash | 19(55.6) | 23(37.7) | 0.087 | 4(11.7) | 5(8.2) | 0.569 |
Nail changes | 7(20.6) | 20(32.8) | 0.268 | 1(2.9) | 0(0.0) | 0.178 |
Constipation | 10(29.4) | 6(10.0) | 0.007 | 0(0.0) | 0(0.0) | |