Notch signaling pathway: a comprehensive prognostic and gene expression profile analysis in breast cancer

BMC Cancer

Table 4 Relative expression of Notch signaling gene in different breast cancer tumor grades

Genes		Grades		Genes		Grades		Genes		Grades
	I vs. II	I vs. III	II vs. III		I vs. II	I vs. III	II vs. III		I vs. II	I vs. III	II vs. III
NOTCH-1	0.3595	0.1562	< 0.0001	NOTCH-2	0.2223	0.0866	0.8627	NOTCH-3	< 0.0001	0.0010	0.0569
JAG1	0.0042	< 0.0001	< 0.0001	DLL1	0.0297	0.0060	0.7474	LFNG	0.0996	< 0.0001	< 0.0001
ST3GAL6	0.6187	0.5527	0.0002	FBXW11	0.0074	0.4546	< 0.0001	DTX1	0.1873	0.0427	0.7705
DTX2	0.7623	0.4963	< 0.0001	DTX4	0.0731	0.0210	0.0193	CUL1	0.6856	0.2127	< 0.0001
ARRB1	< 0.0001	< 0.0001	< 0.0001	SKP1	0.9002	< 0.0001	< 0.0001	RBX1	0.6319	0.0266	0.0094
KAT2A	0.0016	0.0025	0.0007	MAML2	0.2901	0.0076	< 0.0001	PPARD	0.0005	0.4582	< 0.0001
TCF7L2	0.2331	0.0683	0.1344	PSENEN	0.3173	0.9196	0.0917	PSEN2	0.0272	0.0432	0.0002
APH1A	0.1841	0.5830	0.0619	PRKCα	0.1473	0.1239	< 0.0001	SAP30	0.0215	< 0.0001	< 0.0001
HEYL	0.0758	< 0.0001	< 0.0001	HES1	0.2821	0.1110	< 0.0001	CCND1	0.2042	0.0005	< 0.0001
WNT2	0.0524	< 0.0001	< 0.0001	WNT5A	0.0713	< 0.0001	< 0.0001	FZD1	0.2537	0.1015	< 0.0001
FZD5	0.4319	0.0017	< 0.0001	FZD7	0.7096	0.4725	0.0049

Representative statistics (P-values) between different tumor grades have been summarized. Data were analyzed by one-way ANOVA followed by Tukey’s post hoc test. Statistically significant values of (P-value*: P-value < 0.05, **: P-value < 0.001, ***: 0.0001 < P-value = 0.0001, ****: P-value < 0.0001) were determined

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