Notch signaling pathway: a comprehensive prognostic and gene expression profile analysis in breast cancer

BMC Cancer

Table 3 Relative expression of Notch signaling gene in different breast cancer tumor stages

Genes			Stages				Genes			Stages
	I vs. II	I vs. III	I vs. IV	II vs. III	II vs. IV	III vs. IV		I vs. II	I vs. III	I vs. IV	II vs. III	II vs. IV	III vs. IV
NOTCH-1	0.0143	0.0107	0.0417	0.0069	0.7524	0.7778	NOTCH-2	0.3502	0.5768	0.3490	0.2090	0.7943	0.4366
NOTCH-3	< 0.0001	< 0.0001	0.0066	0.0007	0.3834	0.6573	JAG1	0.0002	0.1228	0.2212	0.8496	0.1270	0.6334
DLL1	0.0095	0.1667	0.2689	0.0913	0.4634	0.5982	LFNG	< 0.0001	0.3275	0.0333	0.0001	0.0229	0.7558
ST3GAL6	0.2210	0.6782	0.8930	0.2689	0.8747	0.9107	FBXW11	0.5876	0.0989	0.7855	0.0433	0.2275	0.9528
DTX1	0.7220	0.3348	0.2996	0.1933	0.2182	0.2814	DTX2	0.3956	< 0.0001	0.0718	0.0002	0.6390	0.0080
DTX4	0.4932	0.0323	0.1619	0.2424	0.8120	0.1464	CUL1	0.0224	0.0188	0.4039	0.0006	0.1450	0.2370
ARRB1	< 0.0001	0.2355	0.5304	0.9458	0.9218	0.5142	SKP1	0.7262	0.0016	0.1474	0.0032	0.6744	0.2024
RBX1	0.8067	0.6752	0.0804	0.3725	0.7382	0.6261	KAT2A	0.6120	0.8310	0.0245	0.9514	0.2406	0.5996
MAML2	0.3685	0.7398	0.6783	0.4737	0.2906	0.7233	PPARD	0.8883	< 0.0001	0.9781	< 0.0001	0.6905	0.9056
TCF7L2	0.2857	0.4813	0.1489	0.8292	0.0542	0.8509	PSENEN	0.0176	0.5459	0.1281	0.3245	0.6504	0.4252
PSEN2	0.8642	0.3681	0.0179	0.8279	0.0279	0.7245	APH1A	0.0030	0.8784	0.0209	0.0489	0.1758	0.4034
PRKCα	0.0004	0.6957	0.7418	0.0812	0.5846	0.6706	SAP30	0.0094	0.1345	0.1695	0.0162	0.5657	0.7915
HEYL	0.0049	0.0604	0.0026	0.0566	0.0016	0.1162	HES1	0.0787	0.1622	0.0092	0.0148	0.9601	0.7395
CCND1	0.0025	0.0862	0.3752	0.8402	0.0152	0.0318	WNT2	0.1826	0.2662	0.1033	0.7807	0.7522	0.1974
WNT5A	0.2552	0.4074	0.5965	0.0062	0.2165	0.1957	FZD1	0.0108	0.0017	0.0155	0.1708	0.6474	0.9315
FZD5	0.6428	0.6570	0.4258	0.7177	0.0031	0.5106	FZD7	0.2082	0.0366	0.5839	0.2594	0.8440	0.7226

Representative statistics (P-values) between different tumor stages have been reported. Data were analyzed by one-way ANOVA followed by Tukey’s post hoc test. Statistically significant values of (P-value*: P-value < 0.05, **: P-value < 0.001, ***: 0.0001 < P-value = 0.0001, ****: P-value < 0.0001) were determined

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