Table 1 Trial flowchart
Preliminary investigations | Radiotherapy: | |
|---|---|---|
‐ CT-simulation | ||
‐ MRI for radiotherapy planning | ||
‐ Completing the questionnaire | ||
Surgery: | ||
‐ Pre-operative consultation anesthesia | ||
‐ Completing the questionnaire | ||
Start hormone therapy (14 days before the metastasis-directed therapy) | Group A | / |
Group B | start hormone therapy for 1 month | |
Group C | start first-line hormone therapy + second-line hormone therapy for 6 months | |
Metastasis-directed therapy | - Surgery - Radiotherapy: 3–7 irradiation treatments, max 3x/week | |
End of Radiotherapy | - Standard follow-up + blood sample + completing the questionnaire | |
Month 1 | - Standard follow-up + blood sample + completing the questionnaire | |
Month 3 | ||
Month 6 | ||
Month 9 and every 3 months thereafter | - Standard follow-up + blood sample + completing the questionnaire at month 12 and 24 | |