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Table 1 Characteristics of subgroup (by the NanoString assay)

From: Molecular subgrouping of medulloblastoma in pediatric population using the NanoString assay and comparison with immunohistochemistry methods

Clinical Features

Number of Cases (%) or value

WNT (N = 14)

SHH (N = 20)

Group 3 (N = 18)

Group 4 (N = 39)

P value

Gender

    

0.003

  M

3 (21.4%)

11 (55.0%)

14 (77.8%)

28 (71.8%)

 

  F

11 (78.6%)

9 (45.0%)

4 (22.2%)

11 (28.2%)

 

Age (years)

    

0.007

   ≤ 3

1 (7.1%)

7 (35.0%)

7 (38.9%)

3 (7.7%)

 

  3–18

13 (92.9%)

13 (65.0%)

11 (61.1%)

36 (92.3%)

 

Metastasis at diagnosis

    

0.096

  Negative

11 (78.6%)

14 (70.0%)

7 (38.9%)

25 (64.1%)

 

  Positive

3 (21.4%)

6 (30.0%)

11 (61.1%)

14 (35.9%)

 

Tumor location

    

 < 0.001

  Midline

8 (57.1%)

8 (40.0%)

18 (100.0%)

39 (100.0%)

 

  Hemispheric

0 (0.0%)

12 (60.0%)

0 (0.0%)

0 (0.0%)

 

  Peduncle

6 (42.9%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

 

Histology

    

0.018

  Classic

13 (92.9%)

5 (25.0%)

10 (55.6%)

27 (69.2%)

 

  MBEN

0 (0.0%)

5 (25.0%)

4 (22.2%)

5 (12.8%)

 

  DN

1 (7.1%)

4 (20.0%)

1 (5.6%)

2 (5.1%)

 

  LCA

0 (0.0%)

6 (30.0%)

3 (16.7%)

5 (12.8%)

 
  1. Abbreviations: WNT Wingless signaling-activated, SHH Sonic-hedgehog signaling-activated, MBEN Medulloblastoma with extensive nodularity, DN Desmoplastic/nodular, LCA Large cell/anaplastic
  2. P values were calculated using the the chi-square test for independence