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Fig. 2 | BMC Cancer

Fig. 2

From: Increased prevalence of human papillomavirus in fresh tissue from penile cancers compared to non-malignant penile samples: a case-control study

Fig. 2

A (top left). Verrucous carcinoma. Note exophytic growth pattern and pushing borders. B (top middle). Invasive squamous cell carcinoma, usual type. Note basal and parabasal atypia with retained keratinization and a mild stromal response. C (top right). P16-immunohistochemical staining did in rare instances, showed a non-specific focal and cytoplasmatic positivity in cancer of usual types and associated differentiated PeIN. D (bottom left). Warty carcinoma. Exophytic growth pattern with complex fused papillae and poorly defined borders. E (bottom middle). Invasive basaloid carcinoma. Note abrupt keratinization and slight stromal response. F (bottom right). Typical positive reaction for P16 in basaloid carcinoma

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