Multiplexed immunofluorescence analysis of CAF-markers, EZH2 and FOXM1 in gastric tissue: associations with clinicopathological parameters and clinical outcomes

Table 3 Univariate and multivariate analyses of clinicopathological factors for disease-free survival in gastric cancer patients

Variable	Univariate analysis		Multivariate analysis
Variable	HR (95% CI)	p^a	HR (95% CI)	p^a
Age (≥ 60/< 60)	0.759 (0.397-1.453)	0.406
Gender (Male/Female)	0.880 (0.402-1.926)	0.748
Location (Cardia/Fundus/ Antrum/Other)	1.103 (0.762-1.597)	0.603
Tumor mass size (≥ 5/< 5)	1.384 (0.694-2.759)	0.356
Histologic grade (Poor, Undifferented /Good, mod)	1.002 (0.452-2.224)	0.996
Tumor depth (T3, T4/T1, T2)	1.267 (0.579-2.774)	0.554
Vascular invasion (Present/Absent)	2.562 (1.262-5.204)	0.009
Nervous invasion (Present/Absent)	1.530 (0.792-2.954)	0.206
Lymphatic metastasis (Present/Absent)	3.620 (1.406-9.317)	0.008	3.205 (1.237-8.305)	0.017
pTNM stage (III + IV/I + II)	1.780 (0.914-3.466)	0.090
FOXM1 protein (High/Low)	1.075 (0.563-2.053)	0.827
FAP protein (High/Low)	2.534 (1.311-4.899)	0.006	2.218 (1.145-4.297)	0.018
EZH2 protein (High/Low)	2.646 (0.811-8.625)	0.107

HR Hazard ratio, CI confidence interval; ^a All statistical tests were 2-sided. Significance level: p < 0.05

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