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Table 6 Analysis of T cell subsets, IgM, L%, NLR, CRP and D-Dimer in advanced stage (stage III & IV) NSCLC patients

From: Broad-spectrum antibiotics associated gut microbiome disturbance impairs T cell immunity and promotes lung cancer metastasis: a retrospective study

Tumor stage

Non-ATB (n = 104)

ATB(n = 95)

P value

III

96

47

 

IV

8

48

 

CD3+ (%)

69.90(64.60,76.10)

63.20 (53.50,69.50)

< 0.001

CD4+ (%)

43.65 ± 10.30

36.52 ± 10.56

< 0.001

CD8+ (%)

21.71 (16.00,27.80)

20.10 (15.27,23.80)

0.031

CD4/CD8

1.99 (1.39,3.01)

1.79 (1.35,2.38)

0.222

CD16 + 56+ (%)

14.87 (10.30,22.70)

19.10 (13.30,29.40)

0.002

CD19+ (%)

9.10 (5.90,13.15)

9.00 (6.21,12.70)

0.596

IgM (g/L)

0.82 (0.58,1.29)

0.83 (0.55,1.03)

0.162

L%

16.10 (11.20,22.70)

12.40 (8.30,20.20)

0.027

NLR

4.65 (2.93,6.85)

5.88 (3.51,10.16)

0.028

CRP (mg/L)

22.82 (4.63,66.39)

31.59 (7.47,79.03)

0.177

D-Dimer (mg/L)

1.15 (0.59,2.77)

3.18 (1.05,5.42)

< 0.001

  1. L% Percentage of lymphocytes, NLR Neutrophil-lymphocyte ratio, CRP C-reactive protein, IgM Immunoglobulin M