Fig. 4

Development and validation of a prognostic model for GBM patients. A LASSO analysis with 10-fold cross-validation identified four prognostic genes. B, C Survival curves and ROC curves for evaluating the risk stratification ability and predicting the constructed risk models for the TCGA and CGGA cohorts. D Risk maps were used to illustrate the survival status of each sample in the TCGA and CGGA cohorts; heat maps represent the differences in expression of each gene in the risk groups. E, F Principal component analysis between the high- and low-risk groups in TCGA and CGGA entire set. GBM, glioblastoma multiforme; DEGs, differentially expressed genes; LASSO, minimal absolute shrinkage and selection manipulation; ROC, subject operating characteristic curve