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Fig. 2 | BMC Cancer

Fig. 2

From: Expression of hub genes of endothelial cells in glioblastoma-A prognostic model for GBM patients integrating single-cell RNA sequencing and bulk RNA sequencing

Fig. 2

TCGA cohort differential analysis and WGCNA identification of hub genes in GBM development. A Volcano plot of up-and down-regulated DEGs in the TCGA-GTEx cohort. B Scale-free fit indices for soft threshold powers. Soft threshold powerβin WGCNA was determined by the scale-free R2 (R2 = 0.90). The left panel shows the relationship between β and R2. The right panel shows the relationship between soft threshold power β and average connectivity. C Deg tree diagram based on clustering of different metrics. D Heat map illustrating the correlation between different gene modules and clinical features (normal vs. tumor). E Venn diagram between WGCNA module genes and endothelial cell marker genes. F Forest plot of the results of one-way cox analysis of 157 intersecting genes. DEGs, differentially expressed genes; TCGA, cancer genome atlas; GBM, glioblastoma multiforme; WGCNA, weighted gene correlation network analysis

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BMC Cancer

ISSN: 1471-2407

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