Fig. 4

Decision curve analysis of the nomogram. A The benefit in the training set; B The benefit in the validation set. The thick solid gray line indicates treated-for-all scheme and the thin solid gray lines indicate 95% confident interval of treated-for-all scheme. The horizontal black line indicates treated-for-none scheme. The thick solid red line indicates the decision curve with 95% confident interval of it (the thin solid red lines). Cost:benefit ratio was presented in the below of each decision curve. The decision curves are a significant distance from the two reference lines (the treat-for-all scheme and the treat-for-none scheme), suggesting that the nomogram performed well in clinical setting in both the training and validation sets