Artificial intelligence to guide precision anticancer therapy with multitargeted kinase inhibitors

BMC Cancer

Table 2 Experimental validation of drug treatment predictions by CancerOmicsNet. GR_max values obtained for three cell lines treated with six drugs at various concentrations. For each treatment, two values collected from experiment A / experiment B are reported

Drug concentration	Panc 04.03		DU 145		HCC70
Drug concentration	*JNJ-7706621*	*PP1*	*AZD6482*	*XMD8–92*	*GW2580*	*PI-103*
1 nm	−1.000 / -0.596	−1.000 / -0.771	− 0.344 / -0.147	− 0.791 / -0.998	− 0.086 / -0.361	0.176 / -0.077
3.162 nm	−1.000 / -0.807	− 1.000 / -0.830	− 0.908 / -0.968	− 0.892 / -0.992	0.129 / -0.040	0.042 / 0.036
10 nm	− 1.000 / -0.922	− 1.000 / -0.697	− 0.788 / -0.429	− 0.929 / -0.998	0.245 / 0.022	− 0.472 / -0.265
31.62 nm	−1.000 / -0.708	− 1.000 / -0.257	− 0.609 / -0.995	− 0.962 / -0.996	− 0.131 / -0.048	− 0.274 / 0.176
100 nm	− 1.000 / -0.818	− 0.999 / -0.908	− 0.977 / -0.991	− 0.840 / -0.999	− 0.421 / 0.335	0.158 / -0.076
316.2 nm	−0.111 / -0.968	− 1.000 / -0.759	− 0.340 / -0.977	− 0.557 / -0.976	−0.116 / 0.556	− 0.353 / -0.437
1 μm	− 0.570 / -0.982	−1.000 / -0.838	−0.581 / -0.982	− 0.892 / -0.996	0.139 / 0.249	0.238 / -0.330
3.162 μm	−0.026 / -0.665	−1.000 / -0.738	−0.211 / -0.998	− 0.799 / -0.993	−0.206 / -0.345	− 0.943 / -0.884
10 μm	− 0.188 / -0.723	−1.000 / -0.739	−0.987 / -0.995	− 0.714 / -0.852	−0.808 / -0.319	− 0.985 / -0.797

ISSN: 1471-2407