Table 1 Clinicopathologic characteristics of all patients stratified by mSIS
Parameters | Â | High risk | Low risk | P |
|---|---|---|---|---|
N = 305 (%) | n = 65 (%) | n = 240 (%) |  | |
Age (median [IQR]) | 49 [42, 57] | 50 [43, 58] | 49 [41, 56] | 0.053 |
Age | Â | Â | Â | 0.286 |
  ≤ 49 | 161 (52.8) | 30 (46.2) | 131 (54.6) |  |
  > 49 | 144 (47.2) | 35 (53.8) | 109 (45.4) |  |
Position | Â | Â | Â | 0.998 |
 left | 176 (57.7) | 37 (56.9) | 139 (57.9) |  |
 right | 129 (42.3) | 28 (43.1) | 101 (42.1) |  |
BMI | Â | Â | Â | 1 |
  < 24 | 161 (52.8) | 34 (52.3) | 127 (52.9) |  |
  ≥ 24 | 144 (47.2) | 31 (47.7) | 113 (47.1) |  |
Height | Â | Â | Â | 0.168 |
  ≤ 1.6 | 167 (54.8) | 41 (63.1) | 126 (52.5) |  |
  > 1.6 | 138 (45.2) | 24 (36.9) | 114 (47.5) |  |
Weight | Â | Â | Â | 0.479 |
  ≤ 61.5 | 155 (50.8) | 30 (46.2) | 125 (52.1) |  |
  > 61.5 | 150 (49.2) | 35 (53.8) | 115 (47.9) |  |
Menopause | Â | Â | Â | 0.714 |
 no | 168 (55.1) | 34 (52.3) | 134 (55.8) |  |
 yes | 137 (44.9) | 31 (47.7) | 106 (44.2) |  |
Clinical T stage | Â | Â | Â | 0.093 |
 cT1 | 37 (12.1) | 8 (12.3) | 29 (12.1) |  |
 cT2 | 208 (68.2) | 39 (60.0) | 169 (70.4) |  |
 cT3 | 55 (18.0) | 15 (23.1) | 40 (16.7) |  |
 cT4 | 5 (1.6) | 3 (4.6) | 2 (0.8) |  |
Clinical N stage | Â | Â | Â | 0.117 |
 cN0 | 13 (4.3) | 3 (4.6) | 10 (4.2) |  |
 cN1 | 29 (9.5) | 3 (4.6) | 26 (10.8) |  |
 cN2 | 184 (60.3) | 47 (72.3) | 137 (57.1) |  |
 cN3 | 79 (25.9) | 12 (18.5) | 67 (27.9) |  |
Clinical TNM stage | Â | Â | Â | 0.271 |
 I + II | 38 (12.5) | 5 (7.7) | 33 (13.8) |  |
 III | 267 (87.5) | 60 (92.3) | 207 (86.2) |  |
Molecular subtype | Â | Â | Â | 0.631 |
 luminal A | 39 (12.8) | 9 (13.8) | 30 (12.5) |  |
 luminal B | 135 (44.2) | 25 (38.5) | 110 (45.8) |  |
 HER-2 OE | 71 (23.3) | 15 (23.1) | 56 (23.3) |  |
 TNBC | 60 (19.7) | 16 (24.6) | 44 (18.3) |  |
ER status | Â | Â | Â | 0.479 |
 negative | 136 (44.6) | 32 (49.2) | 104 (43.3) |  |
 positive | 169 (55.4) | 33 (50.8) | 136 (56.7) |  |
PR status | Â | Â | Â | 0.892 |
 negative | 169 (55.4) | 37 (56.9) | 132 (55.0) |  |
 positive | 136 (44.6) | 28 (43.1) | 108 (45.0) |  |
HER-2 status | Â | Â | Â | 0.527 |
 negative | 111 (36.4) | 23 (35.4) | 88 (36.7) |  |
 low expression | 87 (28.5) | 22 (33.8) | 65 (27.1) |  |
 positive | 107 (35.1) | 20 (30.8) | 87 (36.2) |  |
Ki-67 index | Â | Â | Â | 0.188 |
  ≤ 14% | 103 (33.8) | 17 (26.2) | 86 (35.8) |  |
  > 14% | 202 (66.2) | 48 (73.8) | 154 (64.2) |  |
P53 status | Â | Â | Â | 0.209 |
 negative | 214 (70.2) | 41 (63.1) | 173 (72.1) |  |
 positive | 91 (29.8) | 24 (36.9) | 67 (27.9) |  |
Cycle | Â | Â | Â | 0.992 |
  < 4 | 40 (13.1) | 8 (12.3) | 32 (13.3) |  |
  ≥ 4 | 265 (86.9) | 57 (87.7) | 208 (86.7) |  |
pCR | Â | Â | Â | 0.379 |
 no | 249 (81.6) | 56 (86.2) | 193 (80.4) |  |
 yes | 56 (18.4) | 9 (13.8) | 47 (19.6) |  |