Table 2 Univariate and multivariate analysis of overall survival in a whole cohort

Age

1.18

0.7–1.98

0.533

Gender

1.07

0.67–1.69

0.790

Tumor differentiation

0.73

0.45–1.18

0.201

Tumor size

1.43

0.89–2.31

0.142

Microvascular invasion

1.46

0.91–2.34

0.121

Nerve invasion

2.71

1.55–4.76

0.000

2.66

1.5–4.73

0.001

Preoperative CA199 > 37.00u/ml

1.86

1.14–3.02

0.013

1.94

1.18–3.2

0.009

Preoperative TBIL> 17.1 umol/L

1.19

0.62–2.26

0.600

HbsAg positive

0.95

0.6–1.52

0.843

Surgical type

0.51

0.29–0.9

0.021

0.63

0.35–1.13

0.124

Postoperative targeted therapy

0.9

0.5–1.62

0.734

Postoperative adjuvant chemotherapy

0.5

0.3–0.82

0.006

0.51

0.31–0.84

0.009