Table 3 The pooled HRs of OS, PFS, DSS, RFS for four molecular subtypes at univariable and multivariable analyses
| Â | Univariable analyses | Multivariable analyses | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
pooled HR (95%CI) | P of HR | I2 (95%CI) | P of I2 | Number of studies | pooled HR (95%CI) | P of HR | I2 (95%CI) | P of I2 | Number of studies | ||
OS | POLEmut vs. p53wt | 0.69 (0.55–0.87) | 0.0016 | 0.0% (0.0–62.5%) | 0.6952 | 5 | 0.77 (0.60–0.99) | 0.0447 | 0.0% (0.0–83.4%) | 0.4276 | 4 |
MSI vs. p53wt | 1.15 (0.97–1.37) | 0.1054 | 59.9% (1.6–83.7%) | 0.0288 | 6 | 1.08 (0.94–1.25) | 0.2620 | 40.9% (0.0–78.2%) | 0.1489 | 5 | |
p53mt vs p53 wt | 1.40 (1.15–1.71) | 0.0007 | 66.0% (11.3–87.0%) | 0.0192 | 5 | 1.24 (1.09–1.40) | 0.0009 | 0.0% (0.0–80.0%) | 0.5141 | 4 | |
PFS | POLEmut vs. p53wt | 0.66 (0.42–1.04) | 0.0743 | 0.0% (0.0–76.3%) | 0.6447 | 3 | 0.53 (0.32–0.87) | 0.0112 | 0.00% | 0.7927 | 2 |
MSI vs. p53wt | 1.29 (0.92–1.82) | 0.1421 | 59.9% (0.0–88.6%) | 0.0828 | 3 | 1.01 (0.88–1.15) | 0.9029 | 7.90% | 0.2973 | 2 | |
p53mt vs p53 wt | 1.81 (1.24–2.66) | 0.0023 | 79.2% (33.7–93.5%) | 0.0082 | 3 | 1.23 (1.04–1.46) | 0.0186 | 0.00% | 0.8026 | 2 | |
DSS | POLEmut vs. p53wt | 0.81 (0.52–1.26) | 0.3392 | 0.0% (0.0–13.3%) | 0.9123 | 4 | 0.62 (0.36–1.07) | 0.0867 | 0.0% (0.0–21.5%) | 0.8759 | 3 |
MSI vs. p53wt | 1.04 (0.69–1.57) | 0.8534 | 74.8% (30.1–90.9%) | 0.0076 | 4 | 1.02 (0.84–1.24) | 0.8258 | 0.0% (0.0–47.6%) | 0.8199 | 3 | |
p53mt vs p53 wt | 1.77 (1.51–2.09) | < 0.0001 | 16.5% (0.0–87.2%) | 0.3087 | 4 | 1.34 (1.09–1.66) | 0.0051 | 0.0% (0.0–62.5%) | 0.7579 | 3 | |
RFS | POLEmut vs. p53wt | 0.46 (0.29–0.74) | 0.0015 | 0.00% | 0.9695 | 2 | 0.50 (0.31–0.80) | 0.0038 | 0.00% | 0.5722 | 2 |
MSI vs. p53wt | 0.92 (0.81–1.06) | 0.2449 | 0.0% (0.0–86.9%) | 0.4521 | 3 | 0.89 (0.78–1.02) | 0.1035 | 34.6% (0.0–78.7%) | 0.2167 | 3 | |
p53mt vs p53 wt | 1.47 (1.14–1.89) | 0.0030 | 50.9% (0.0–85.8%) | 0.1306 | 3 | 1.35 (1.04–1.74) | 0.0221 | 49.0% (0.0–85.2%) | 0.141 | 3 | |