Table 2 The pooled frequency of POLEmut ECs according to clinicopathology characteristics
Clinicopathological characteristics in EC | Pooled frequency of POLEmut (95% CI), (%) | No. of studies | I2 (95% CI), (%) | P for I2 | Model | Egger’s test |
|---|---|---|---|---|---|---|
Overall POLEmut | 7.95 (6.52–9.51) | 50 | 86.3 (82.7–89.1) | < 0.0001 | Random effect | z = 1.832, P = 0.06695 |
EEC | 7.95 (6.55–9.46) | 32 | 79.6 (71.8–85.2) | < 0.0001 | Random effect | z = 2.5622, P = 0.0104 |
NEEC | 4.45 (2.63–6.61) | 30 | 56.0 (33.7–70.8) | 0.0001 | Random effect | z = 1.018, P = 0.3087 |
Grade 1–2 | 5.35 (4.16–6.67) | 23 | 57.2 (31.9–73.1) | 0.0004 | Random effect | z = 1.0836, P = 0.2785 |
Grade 3 | 10.55 (8.35–12.94) | 27 | 66.6 (50.0–77.7) | < 0.0001 | Random effect | z = 0.50043, P = 0.6168 |
FIGO stage I-II | 9.15 (7.06–11.46) | 29 | 80.8 (73.2–86.3) | < 0.0001 | Random effect | z = 2.7772, P = 0.005483 |
FIGO stage II-IV | 3.08 (1.72–4.71) | 30 | 51.9 (26.9–68.3) | 0.0006 | Random effect | z = 0.66061, P = 0.5089 |
FIGO stage III-IV | 2.89 (1.43–4.67) | 28 | 39.4 (4.6–61.6) | 0.0180 | Random effect | z = 0.25724, P = 0.797 |
LVSI absent | 6.96 (5.32–8.77) | 17 | 68.3 (47.6–80.8) | < 0.0001 | Random effect | z = 1.7728, P = 0.07626 |
LVSI present | 6.40 (3.82–9.48) | 17 | 75.1 (60.0–84.5) | < 0.0001 | Random effect | z = 0.24716, P = 0.8048 |
Myometrial invasion≥50% | 4.78 (3.47–6.28) | 11 | 39.6 (0.0–70.3) | 0.0846 | Random effect | z = 0.70065, P = 0.4835 |
Myometrial invasion< 50% | 6.85 (5.04–8.89) | 11 | 65.5 (34.5–81.8) | 0.0013 | Random effect | z = 0.93704, P = 0.3487 |
Lymph node status absent | 9.46 (7.77–11.28) | 7 | 0.0 (0.0–45.4) | 0.7823 | Fixed effect | z = −0.75094, P = 0.4527 |
Lymph node status present | 4.97 (0.55–12.07) | 7 | 66.0 (23.9–84.8) | 0.0072 | Random effect | z = − 0.30722, P = 0.7587 |
Risk stratification-low | 5.87 (3.81–8.30) | 5 | 0.0 (0.0–0.0) | 0.9660 | Fixed effect | z = 0, P = 1 |
Risk stratification-intermediate | 7.18 (1.07–16.78) | 5 | 69.4 (21.5–88.0) | 0.0110 | Random effect | z = 0, P = 1 |
Risk stratification-high | 8.87 (6.07–12.09) | 7 | 52.1 (0.0–79.6) | 0.0512 | Random effect | z = −0.15019, P = 0.8806 |
With adjuvant therapy | 9.00 (6.78–11.46) | 15 | 60.5 (30.6–77.6) | 0.0012 | Random effect | z = 0.14846, P = 0.8820 |
Without adjuvant therapy | 6.27 (4.11–8.75) | 14 | 47.0 (1.4–71.5) | 0.0266 | Random effect | z = 0.4927, P = 0.6222 |