Table 2 Univariate and multivariate Cox regression analysis of clinical factors. (HR: hazard ratio; CI: confidence interval)

TCGA

Age

1.035 (1.019 ~ 1.051)

1.82e-05*

1.039 (1.018 ~ 1.061)

Gender-male

0.872 (0.630 ~ 1.206)

0.407

Pathological Stage

1.703 (1.405 ~ 2.064)

5.63e-08*

1.236 (0.615 ~ 2.485)

T stage

1.702 (1.353 ~ 2.142)

5.79e-06*

1.173 (0.806 ~ 1.706)

Histological grade

2.915 (0.721 ~ 11.78)

0.133

Lymphatic metastasis

2.227 (1.625 ~ 3.051)

6.29e-07*

0.967 (0.385 ~ 2.427)

Angiolymphatic invasion

2.339 (1.601 ~ 3.416)

1.1e-05*

1.711 (1.054 ~ 2.777)

Risk score

3.584 (2.455 ~ 5.233)

3.84e-11*

2.521 (1.455 ~ 4.367)