Fig. 4

DNA methylation of MAPK8IP2 is strongly associated with PCa. A Heatmap comparing the DNA methylation levels of MAPK8IP2 between normal tissue and primary tumor tissue (UCSC Xena). B-E MAPK8IP2 promoter methylation profile based on sample type (B), patient race (C), patient age (D), and nodal metastasis status (E) (UALCAN). F-H Diagnostic model for PCa based on CpG sites located within MAPK8IP2, the model includes a bar plot of important score (F), ROC curve (G), and clustering heatmap of importance CpG sites (H) (DNMIVD). I, J Kaplan–Meier curves comparing DFI (I),and PFI (J) in the low and high groups of DNA methylation of MAPK8IP2 (DNMIVD). ROC: receiver operating characteristic; DFI: disease free interval; PFI: progression-free interval. *p < 0.05, **p < 0.01, ***p < 0.001