Fig. 6

Subclonal architecture of 9 mice and relationships between subclones were revealed by phylogenetic trees in three mice. A Two-dimensional scatter plots show the CCF of the mutations among different tumor cells. Each subclone was acquired by clusting of the CCF in tumor cells from different organs. B-D Phylogenetic trees of mouse1–3: Branch length was proportional to the number of substitution mutations in each subclone. The trunk branch represents subclones originating from the primary lesion, and the subbranch represents unique subclones from different tissues. Tissue resources were annotated at the end of the branch, and oncogenic genes with driver mutations were annotated on the side of the branch