HERPUD1 promotes ovarian cancer cell survival by sustaining autophagy and inhibit apoptosis via PI3K/AKT/mTOR and p38 MAPK signaling pathways

Table 2 Association between HERPUD1 and Lewis y expression and pathological features in ovarian cancer

Features	Cases	HERPUD1			Lewis y
Features	Cases	High expression Cases	High expression rate%	P-value	High expression Cases	High expression rate%	P-value
FIGO stage				0.016*			0.01*
I-II	34	24	70.6		16	47.1
III-IV	52	23	44.2		42	80.8
Differentiation				0.123			0.012*
Well-Moderate	30	13	43.3		15	50.0
Poorly	56	34	60.7		43	76.8
LN metastasis				0.604			0.006**
No	46	24	52.2		24	52.2
Yes	22	10	45.5		19	86.4
no lymphadenectomy	18	13	72.2		15	83.3
Pathologic type
Serous	47	20	42.6	0.001***	25	53.2
Mucinous	4	3	75.0		3	75.0
Clear cell carcinoma	7	3	42.9	0.011*	5	71.4
Endometrioid	11	11	100.0		11	100.0	0.004**
Poorly differentiated adenocarcinoma	17	10	58.8	0.023*	14	82.4	0.044*

Abbreviations: FIGO International Federation of Gynecology and Obstetrics, LN Lymph nodes
*p < 0.05, **p < 0.01,***p < 0.001

ISSN: 1471-2407