Skip to main content
Fig. 7 | BMC Cancer

Fig. 7

From: HERPUD1 promotes ovarian cancer cell survival by sustaining autophagy and inhibit apoptosis via PI3K/AKT/mTOR and p38 MAPK signaling pathways

Fig. 7

HERPUD1 regulates the expression of autophagy-related proteins, EMT-related proteins and ERS-related proteins in CAOV3 and SKOV3 ovarian cancer cell lines. a, b In CAOV3 and SKOV3 ovarian cancer cell lines, knockdown of HERPUD1 reduced the expression of protein p27, Atg5, Beclin1, and reduced the LC3 II/I ratio, but increased the expression of protein p62. a, c In CAOV3 and SKOV3 ovarian cancer cell lines, knockdown of HERPUD1 reduced the expression of E-cadherin and Timp2, but increased the expression of N-cadherin. a, d In CAOV3 and SKOV3 ovarian cancer cell lines, knockdown of HERPUD1 reduced the expression of ERS marker protein GRP78 and GRP94. Due to the different transfer conditions, the antibody incubation was performed after the membrane was cut. Data are presented as the mean ± SEM (n = 3 per group), *P < 0.05, **P < 0.01,*** P < 0.001 vs. the NC group

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us