Table 3 Univariate and multivariate analysis for OS

transversions vs. the others

HR 1.33 (95% CI: 0.77–2.31),

-

(KRAS WT and transitions)

p = 0.33

transitions vs. the others

HR 3.74 (95% CI: 1.97–7.10),

HR 2.84 (95% CI: 1.47–5.51),

(KRAS WT and transversions)

p < 0.01

p < 0.01

Age:

HR 0.51 (95% CI: 0.36–0.70),

HR 0.52 (95% CI: 0.37–0.74),

 < 70 vs. ≥ 70

p < 0.01

p < 0.01

Sex:

HR 2.15 (95% CI: 1.55–2.97),

HR 1.19 (95% CI: 0.73–1.96),

 Male vs. Female

p < 0.01

p = 0.49

Smoking:

HR 0.39 (95% CI: 0.28–0.55),

HR 0.64 (95% CI: 0.38–1.09),

 Never vs. current / ever

p < 0.01

p = 0.10

Histology:

HR 2.44 (95% CI: 1.73–3.44),

HR 1.45 (95% CI: 0.97–2.15),

 Sq vs. non-sq

p < 0.01

p = 0.07

Stage:

HR 0.25 (95% CI: 0.18–0.34),

HR 0.29 (95% CI: 0.21–0.40),

 I vs. (II, III, IV)

p < 0.01

p < 0.01

Mutations:

HR 0.78 (95% CI: 0.55–1.12),

-

 0 vs. ≥ 1

p = 0.17

BMI:

HR 0.84 (95% CI: 0.61–1.15),

-

 < 22.5 vs. ≥ 22.5

p = 0.27

High fat diet:

HR 1.63 (95% CI: 1.19–2.23),

HR 1.23 (95% CI: 0.89–1.71),

 ≤ 2/ week vs. ≥ 3/ week

p < 0.01

p = 0.21

Vegetables:

HR 1.82 (95% CI: 1.15–2.89),

HR 1.63 (95% CI: 1.00–2.65),

 ≤ 2/ week vs. ≥ 3/ week

p = 0.02

p = 0.05

Fruits:

HR 1.14 (95% CI: 0.82–1.58),

-

 ≤ 2/ week vs. ≥ 3/ week

p = 0.44

Soy bean:

HR 1.36 (95% CI: 0.92–2.03),

-

 ≤ 2/ week vs. ≥ 3/ week

p = 0.14

Exercise:

HR 0.99 (95% CI: 0.73–1.35),

-

 ≤ 2/ week vs. ≥ 3/ week

p = 0.95