Table 2 Univariate and multivariate analysis for RFS

transversions vs. the others

HR 1.10 (95% CI: 0.69–1.75),

-

(KRAS WT and transitions)

p = 0.71

transitions vs. the others

HR 2.53 (95% CI: 1.38–4.63),

HR 2.15 (95% CI: 1.17–3.97),

(KRAS WT and transversions)

p < 0.01

p = 0.01

Age:

HR 0.36 (95% CI: 0.16–0.84),

HR 0.64 (95% CI: 0.49–0.83),

 < 70 vs. ≥ 70

p < 0.01

p < 0.01

Sex:

HR 1.61 (95% CI: 1.26–2.06),

HR 1.29 (95% CI: 0.90–1.87),

 Male vs. Female

p < 0.01

p = 0.17

Smoking:

HR 0.60 (95% CI: 0.47–0.77),

HR 0.91 (95% CI: 0.62–1.33),

 Never vs. current / ever

p < 0.01

p = 0.62

Histology:

HR 1.51 (95% CI: 1.12–2.04),

HR 0.90 (95% CI: 0.64–1.27),

 Sq vs. non-sq

p < 0.01

p = 0.55

Stage:

HR 0.22 (95% CI: 0.17–0.29),

HR 0.23 (95% CI: 0.18–0.30),

 I vs. (II, III, IV)

p = 0.01

p < 0.01

Mutations:

HR 0.97 (95% CI: 0.73–1.30),

-

 0 vs. ≥ 1

p = 0.81

BMI:

HR 0.79 (95% CI: 0.62–1.01),

-

 < 22.5 vs. ≥ 22.5

p = 0.06

High fat diet:

HR 1.41 (95% CI: 1.10–1.80),

HR 1.15 (95% CI: 0.89–1.49),

 ≤ 2/ week vs. ≥ 3/ week

p < 0.01

p = 0.27

Vegetables:

HR 1.33 (95% CI: 0.89–1.98),

-

 ≤ 2/ week vs. ≥ 3/ week

p = 0.16

Fruits:

HR 0.99 (95% CI: 0.76–1.28),

-

 ≤ 2/ week vs. ≥ 3/ week

p = 0.94

Soy bean:

HR 1.33 (95% CI: 0.97–1.82),

-

 ≤ 2/ week vs. ≥ 3/ week

p = 0.08

Exercise:

HR 0.98 (95% CI: 0.77–1.26),

-

 ≤ 2/ week vs. ≥ 3/ week

p = 0.85