Table 1 Clinical and lifestyle background
KRAS WT (n = 794) No. (%) | Transversions (n = 61) No. (%) | P value* | Transitions (n = 19) No. (%) | P value^ | P value# | |
|---|---|---|---|---|---|---|
Age median (range) | 70.0 (23–92) | 70.0 (49–85) | - | 70.0 (52–86) | - | - |
Sex | 0.02 | < 0.01 | 0.65 | |||
Male | 366 (46.1) | 39 (63.9) | 13 (68.4) | |||
Female | 428 (53.9) | 22 (36.1) | 6 (31.6) | |||
Smoking | < 0.01 | < 0.01 | 0.64 | |||
Never | 413 (52.0) | 18 (29.5) | 5 (26.3) | |||
Ever | 381 (48.0) | 43 (70.5) | 14 (73.7) | |||
Histology | 0.01 | 0.01 | 1.00 | |||
Sq | 138 (17.4) | 3 (4.9) | 1 (5.3) | |||
Non-sq | 656 (82.6) | 58 (95.1) | 18 (94.7) | |||
Stage | 0.30 | 0.84 | 0.77 | |||
I | 568 (71.5) | 38 (62.3) | 12 (63.1) | |||
II | 114 (14.4) | 12 (19.7) | 3 (15.8) | |||
III | 94 (11.8) | 7 (11.5) | 3 (15.8) | |||
IV | 18 (2.3) | 4 (6.5) | 1 (5.3) | |||
No. of Mutations | 0.35 | < 0.01 | 0.04 | |||
0 | 200 (25.2) | 0 | 0 | |||
1 | 384 (48.4) | 35 (57.4) | 8 (42.1) | |||
≥ 2 | 210 (26.4) | 26 (42.6) | 11 (57.9) | |||
BMI | 0.01 | 0.06 | 0.39 | |||
< 22.5 | 402 (50.6) | 20 (32.8) | 7 (36.9) | |||
≥ 22.5 | 389 (49.0) | 40 (65.6) | 12 (63.1) | |||
Unknown | 3 (0.4) | 1 (1.6) | 0 | |||
High fat diets | 0.12 | 0.32 | 0.67 | |||
≤ 2/ week | 313 (39.4) | 31 (50.8) | 9 (47.4) | |||
≥ 3/ week | 477 (60.1) | 30 (49.2) | 10 (52.6) | |||
Unknown | 4 (0.5) | 0 | 0 | |||
Vegetables | 0.01 | 0.13 | 0.47 | |||
≤ 2/ week | 62 (7.8) | 13 (21.3) | 3 (15.8) | |||
≥ 3/ week | 732 (92.2) | 48 (78.7) | 16 (84.2) | |||
Fruits | 0.02 | 0.14 | 0.48 | |||
≤ 2/ week | 249 (31.4) | 29 (47.5) | 8 (42.1) | |||
≥ 3/ week | 545 (68.6) | 32 (52.5) | 11 (57.9) | |||
Soy bean | 0.05 | 0.84 | 0.12 | |||
≤ 2/ week | 112 (14.1) | 16 (26.2) | 3 (15.8) | |||
≥ 3/ week | 681 (85.8) | 45 (73.8) | 16 (84.2) | |||
Unknown | 1 (0.1) | 0 | 0 | |||
Exercise | 1.00 | 0.15 | 0.15 | |||
≤ 2/ week | 409 (51.5) | 32 (52.5) | 12 (63.1) | |||
≥ 3/ week | 385 (48.5) | 29 (47.5) | 7 (36.9) |