Fig. 5

Anti-tumor efficacy of B7-H3 CAR-T cells against PDX models of osteosarcoma in vivo. A and G Schema of the experimental events and nodes. The tumor size (B and H) and mice weight (F and J) variation with B7-H3 CAR-T cells and control T cells injection among the Observed time. C Presence of CD3 + T cells in mouse peripheral blood after 10 days of injection. D Absence of CAR-T cells in mice tumors after 10 days of injection. E Size of tumor mass differed in B7-H3 CAR-T cells, NC T cells or PBS treated mice. I Kaplan–Meier curves for survival of the PDX-OSTE0007 models are shown. (mean ± SEM; ns not significant P > 0.05, *P < 0.05,**P < 0.01, ***P < 0.001)