Table 4 Association of NED status and clinicopathological features in 74 eligible patients
Characteristics | NED, n (%) (n = 41) | Non-NED, n (%) (n = 33) | χ2 | P value |
|---|---|---|---|---|
Gender | ||||
Male | 25 (33.8) | 20 (27.0%) | 0.001 | 0.974 |
Female | 16 (21.6) | 13 (17.6%) | ||
Age (years) | ||||
< 60 | 17 (23.0) | 20 (27.0%) | 2.680 | 0.102 |
> / = 60 | 24 (32.4) | 13 (17.6%) | ||
Primary tumor location: distance from the anal verge (cm) | ||||
> 5 | 26 (35.1) | 20 (27.0%) | 0.061 | 0.804 |
≤ 5 | 15 (20.3) | 13 (17.6%) | ||
Type of local recurrence | ||||
Anastomotic recurrence | 10 (13.5) | 13 (17.6%) | 2.115 | 0.347 |
Regional lymph node metastasis | 22 (29.7) | 13 (17.6%) | ||
Undetermined pelvic recurrence | 9 (12.2) | 7 (9.5%) | ||
Distant metastasis | ||||
Liver/lung/localized lymph node | 35 (47.3) | 18 (24.3%) | 8.525 | 0.003 |
3 or more organs/structures involved or peritoneal metastases | 6 (8.1) | 15 (20.3%) | ||
Localized abdominal recurrence | ||||
None | 10 (13.5) | 4 (5.4%) | 10.636 | 0.005 |
< / = 3 | 29 (39.2) | 18 (24.3%) | ||
> 3 | 2 (2.7) | 11 (14.9%) | ||
Peritoneal metastases | ||||
None or < / = 5 | 39 (52.7) | 22 (29.7%) | 10.223 | 0.001 |
> 5 | 2 (2.7) | 11 (14.9%) | ||
T stage of primary tumor | ||||
T1-2 | 3 (4.1) | 3 (4.1%) | 1.161 | 0.560 |
T3 | 25 (33.8) | 16 (21.6%) | ||
T4 | 13 (17.6) | 14 (18.9%) | ||
N stage of primary tumor | ||||
N0 | 17 (23.0) | 12 (16.2%) | 2.920 | 0.232 |
N1 | 17 (23.0) | 19 (25.7%) | ||
N2 | 7 (9.5) | 2 (2.7%) | ||
Tumor grade of primary tumor | ||||
G1-2 | 30 (40.5) | 27 (36.5%) | 0.773 | 0.379 |
G3 | 11 (14.9) | 6 (8.1%) | ||
Preoperative treatment of primary tumor | ||||
Chemoradiotherapy or radiotherapy | 16 (21.6) | 7 (9.5%) | 2.708 | 0.100 |
None | 25 (33.8) | 26 (35.1%) | ||
Treatment modality | ||||
Single treatment | 8 (10.8) | 7 (9.5%) | 0.033 | 0.857 |
Multiple treatment | 33 (44.6) | 26 (35.1%) | ||