Table 3 Univariate and multivariate Cox regression analysis for survival
Related factors | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Gender | 0.296 | |||||
Male | 1.000 | |||||
Female | 0.658 | 0.300–1.433 | ||||
Age (years) | 0.333 | |||||
< 60 | 1.000 | |||||
≥ 60 | 0.691 | 0.327–1.460 | ||||
Primary tumor location: distance from the anal verge (cm) | 0.856 | |||||
> 5 | 1.000 | |||||
≤ 5 | 0.933 | 0.443–1.965 | ||||
Type of local recurrence | 0.159 | |||||
Anastomotic recurrence | 1.000 | |||||
Regional lymph node metastasis | 0.461 | 0.205–1.038 | ||||
Undetermined pelvic recurrence | 0.565 | 0.182–1.751 | ||||
Distant metastasis | 0.023 | 0.068 | ||||
Liver/lung/localized lymph node | 1.000 | 1.000 | ||||
3 or more organs/structures involved or peritoneal metastases | 2.464 | 1.132–5.362 | 2.106 | 0.947–4.684 | ||
Localized abdominal recurrence | 0.060 | |||||
0 | 1.000 | |||||
1–3 | 0.695 | 0.279–1.734 | ||||
> 3 | 2.011 | 0.696–5.806 | ||||
Peritoneal metastases | 0.023 | 0.513 | ||||
0–5 | 1.000 | 1.000 | ||||
> 5 | 2.637 | 1.140–6.099 | 1.380 | 0.526–3.623 | ||
Type of surgery of primary tumor | 0.268 | |||||
Anterior resection | 1.000 | |||||
Abdominoperineal resection | 2.064 | 0.857–4.971 | ||||
Others | 1.111 | 0.257–4.815 | ||||
T stage of primary tumor | 0.362 | |||||
T1-2 | 1.000 | |||||
T3 | 1.668 | 0.220–12.624 | ||||
T4 | 0.965 | 0.121–7.668 | ||||
N stage of primary tumor | 0.424 | |||||
N0 | 1.000 | |||||
N1 | 0.979 | 0.441–2.174 | ||||
N2 | 1.904 | 0.652–5.565 | ||||
Tumor grade of primary tumor | 0.199 | |||||
G1-2 | 1.000 | |||||
G3 | 0.551 | 0.222–1.368 | ||||
Preoperative treatment of primary tumor | 0.242 | |||||
Chemoradiotherapy or radiotherapy | 1.000 | |||||
None | 1.801 | 0.673–4.822 | ||||
Time to recurrence | 0.233 | |||||
< 24 months | 1.000 | |||||
24–36 months | 3.074 | 0.835–11.315 | ||||
> 36 months | 1.779 | 0.599–5.290 | ||||
No evidence of disease | 0.014 | 0.032 | ||||
NED | 1.000 | 1.000 | ||||
Non-NED | 2.727 | 1.229–6.049 | 2.419 | 1.078–5.427 | ||